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If a cell gets too big it won't be able to get rid of metabolites and acquire nurishment from the environment and end up dead. Metabolites and nurishment get to the cell through cell membrane, nurishment is needed for every thing insede the cell and metabolites are made by all metabloic reactions inside the cell. Thinking geometrically, it's ratio of volume to perimeter that matters, when cell grows it's volume increases faster than perimeter (membrane) and, thus it is at some impossible for the membrane to do it's job properly.

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