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Bacteria can be capsulated or non-capsulated.

When it has no capsule (barrier), it is non-virulent.

When it is capsulated, it is extremely virulent. Bacterial capsule is made of Glycocalyx - a sugar coat ( e.g. mix of Glycopeptide, peptide and polysaccheride) is well organized adheres strongly to bacterial cell membrane in such a way that no antigen or anibody can penetrate the bacterial cell membrane; allowing the bacteria extremely virulent and lethal.

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