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Nondisjunction, the failure of chromosomes to separate properly during cell division, is more common in older females primarily due to the aging of oocytes (egg cells). Women are born with a finite number of eggs, which remain in a dormant state until ovulation, and as they age, the likelihood of errors in chromosome segregation increases. This is linked to the prolonged period of meiosis that eggs undergo, leading to potential issues with spindle formation and chromosomal alignment. Additionally, age-related changes in the cellular environment may further contribute to the increased risk of nondisjunction in older females.

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Related Questions

Why is non disjunction common in older women?

Nondisjunction, the failure of chromosomes to separate properly during cell division, is more common in older women primarily due to the aging of oocytes (egg cells). As women age, their eggs are in a prolonged state of meiosis, which increases the likelihood of errors occurring during chromosome segregation. Additionally, the cellular mechanisms that ensure accurate chromosome separation may become less effective over time, leading to a higher risk of nondisjunction events. This is why older maternal age is associated with higher rates of chromosomal abnormalities, such as Down syndrome.


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Why does the mother's age matter in nondisjunction?

Mother's age is a significant factor in nondisjunction because the likelihood of chromosomal errors during meiosis increases as a woman ages. This is primarily due to the fact that a woman's eggs are formed during fetal development and remain in a suspended state until ovulation, leading to potential deterioration of the egg's chromosomal integrity over time. As a result, older mothers have a higher risk of having children with chromosomal abnormalities, such as Down syndrome, which is linked to nondisjunction events.


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