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Systemic effect refers to an adverse health effect that takes place at a location distant from the body's initial point of contact and presupposes absorption has taken place. Examples: arsenic effects to the blood, nervous system, liver, kidneys and skin; benzene effects to the bone marrow.

Substances with systemic effects often have "target organs" in which they accumulate and exert their toxic effect. Some substances that cause systemic effects are cumulative poisons. These substances tend to build up in the body as a result of numerous chronic exposures. The effects are not seen until a critical body burden is reached. Example: heavy metals such as lead.

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The word that describes "pertaining to the body as a whole" is "systemic".Here are a couple examples in sentences:The patient had a localized rash which developed into a systemic reaction to penicillin.The systemic effects of hormones are well-documented.Systemic or anatomical. Body and body habitus also are used to refer to the whole body.


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