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In medicine, ischemia (from Greek ισχαιμία, ischaimía; isch- root denoting a restriction or thinning or to make or grow thin/lean, haema blood) is a restriction in blood supply, generally due to factors in the blood vessels, with resultant damage or dysfunction of tissue. It may also be spelled ischaemia or ischæmia. It also means local anemia in a given part of a body sometimes resulting from congestion (such as vasoconstriction, thrombosis or embolism).

Ischemic means having or showing symptoms of ischemia, while nonischemic means "not related to or showing signs of ischemia".

Ischemia can also be described as an inadequate flow of blood to a part of the body, caused by constriction or blockage of the blood vessels supplying it. Ischemia of heart muscle produces angina pectoris. Ischemic can be part of the brain supplied by particular vessel.

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