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It means very crazy.

Loco = Crazy
Loquisimo = very crazy

the end -isimo - or -isima modifies nouns in Spanish to make them bigger, larger or more significant. (Loco requires the the change of c to qu to preserve the sound)

The opposite is true for the end -ito and -ita - they make things 'smaller'

Perro = dog
Perrito = small dog/puppy

Beso = kiss
Besito = small/tiny kiss

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