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It depends on how you are feeling. Most of the time, a polite response would the same as in English. I'm well. Estoy bien.

There are many other possible responses. If you are happy, "estoy feliz". If you are ill, you could say "Estoy infermo." If you are just mediocre, "más o menos" or "regular". Whatever your condition or mood is.

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15y ago

What else can I help you with?