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Hmmm... it's actually a bit flexible in terms of meaning much like the word "f**k" is in the English language. Basically if someone is telling you "estas de madre" it means you're either being annoying or really intense about something. When someone says that a THING "esta de madre" it usually implies that thing has flaws or is causing a lot of stress.

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13y ago

What else can I help you with?