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Ozonation is most effective in this circumstance by converting COD to BOD. This allows a region to develop a biological culture that can thrive on the improved food source. Ozone does not bring life, so seeding the river with organisms will be required.

Also, ozone does not remove heavy metals, and does not convert all hazardous chemicals into ones that have no other biological concern. It could be a step, even a periodically repeated step, in the process of restoring a river. But not the whole process itself.

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