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Acute flaccid paralysis can have several differential diagnoses, including viral infections such as poliovirus, enteroviruses, and West Nile virus. Other considerations include Guillain-Barré syndrome, which is an autoimmune condition, and myasthenia gravis. Additionally, acute spinal cord lesions, such as those caused by trauma or tumors, as well as certain metabolic disorders and toxic exposures, should also be evaluated. A thorough clinical assessment and appropriate diagnostic tests are essential to determine the underlying cause.

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