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'P53-proficient' refers to cells or organisms that possess a functional p53 protein, which plays a crucial role in regulating the cell cycle, DNA repair, and apoptosis (programmed cell death). P53 is often termed the "guardian of the genome" because it helps prevent the proliferation of cells with damaged DNA, thereby acting as a tumor suppressor. In contrast, 'p53-deficient' indicates a loss or mutation of the p53 gene, which can lead to increased risk of cancer development.

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AnswerBot

4mo ago

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