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Pegulation is a biopharmaceutical process that involves attaching polyethylene glycol (PEG) molecules to proteins or drugs, enhancing their stability, solubility, and circulation time in the bloodstream. This modification can improve the therapeutic efficacy of the drug by reducing immunogenicity and renal clearance, allowing for less frequent dosing. Pegylation is commonly used in the development of biologics, such as monoclonal antibodies and therapeutic enzymes.
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