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You are asking about the Bubonic Plague, also known as the "black death." Unfortunately, due to poor sanitation, as well as to the large numbers of rodents in the city (fleas were carriers of the disease), it spread throughout London in Shakespeare's day, killing thousands of people.

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Q: What disease were many Londoners worried about the crowds in the globe theatre spreading?
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What disease were many Londoners worried about the crowds in the globe spreading?

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