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Iago's plotting. Othello was susceptible to the particular line of attack taken by Iago, because Iago was a genius in spotting people's weaknesses and exploiting them. Othello was secretly unsure of his ability to command love in Desdemona, and so was easily persuaded that she did not love him. But if he had a different weakness, Iago would have exploited that just as effectively. Iago had no difficulty getting Cassio discharged just by knowing that he had a bad head for liquor.

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Q: What led to Othello's downfall?
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