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Several, but I'll simply mention the two largest:

Einstein's equations for General Relativity do not permit a stable Universe; it must be either be expanding or contracting. Einstein recognized this, but refused to accept the obvious idea that our Universe is expanding and had a definite starting point. Instead, he simply "waved his hand" and added a factor in his equations to cancel out a contracting Universe. When it was observed that our Universe is, indeed, expanding; Einstein admitted that his idea was his "biggest blunder."

Literally to his dying day, Einstein refused to accept the most basic idea of quantum mechanics: that our Universe, at its most fundamental level, is uncertain. Einstein agreed that our Universe may give experimental results that resemble that, but felt that the objects "knew" their characteristics prior to being measured (the technical name is "hidden variables.") Experiments over the last 15 years have absolutely ruled out that idea.

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11y ago

What else can I help you with?