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All measurements are subject to uncertainty, so no. You can reduce the uncertainty by being very careful in your weighing procedures and using properly calibrated equipment though.

Even if you were weighing to the tenth of a gram on a balance that has 4 decimal places, and the display reads 0.5000g with a quantity on the platform. You still cannot be absolutely certain that you have measured exactly 5 tenths of a gram. It could be 0.4998g or 0.5002g because of small fluctuations in the atmosphere and electronics or imperfections in the mechanical parts of the scale. It is impossible to make a scale that is 100% precise and accurate because imperfections will always arise. Also you cannot control the environment 100% so there will always be environment influences, even if they are small.

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