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This is an ambiguous question that needs more input.

If you mean a 10-bit YUV format, then the lowest 6 bits (the rightmost bits on paper) are unused.

Least significant means that they have the lowest value. The far right bit when a binary number is written on paper is only significant by one. The far left bit is the most significant and represents half of the maximum value. For instance, 8 bits can contain a value from 0 to 255, meaning there are only 256 possibilities. So the far left bit is significant by 128, the next one by 64, the next by 32, etc.

The same works with standard decimal numbers. The far right digit is the one's place. The next digit to the left is the ten's place. The next is the hundred's place.

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Related Questions

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