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E = Mc2 has little to do with the design of nuclear weapons, it is just a simple unitts conversion equation between energy and mass, just like feet = miles 5280 is a simple units conversion equation between feet and miles.

They are more interested in the fissioning mass and efficiency figures in the design of nuclear weapons. For example in Little Boy about 787 grams of the uranium used fissioned giving an efficiency of about 1%. The actual mass conversion to energyas shown by E = Mc2 is roughly 450e-15 grams converted to energy to give the roughly 15 kiloton yield of Little Boy. This is because c2 is such a large conversion factor!

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