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Propylthiouracil (PTU) is an anti-thyroid medication that inhibits the production of thyroid hormones by interfering with the conversion of T4 to T3 in the periphery. In hypophysectomized individuals (those without a pituitary gland), PTU may still be effective in reducing thyroid hormone levels, as it acts at the level of the thyroid gland, independent of pituitary function.

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