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A radio opaque substance is something that resists the passage of X-Rays, or other radiation. It is often injected into the heart for a coronary angiogram, into the brain for a cerebral angiogram, or into the cerebralspinal fluid for a myelogram. It makes things stand out on an X-Ray or fluoroscope, making it easier to see internal structures and conditions. It can also be injected systemically, to enhance the constrast of an ordinary X-Ray or CT scan.

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