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Controlled burns, extreme trims, grazing livestock, ground covers, herbicide treatments, manual and mechanical removals, mulched rocks, natural predators, and weighted-down black plastic sheeting are ways to kill horehound. The flowering plant in question (Marrubium vulgare) cannot withstand treatment schedules of burning, cutting, solarizing and spraying (particularly with Dicamba, Triclopyr, 2,4-D). Predatory horehound clearwing (Chamaesphecia mysiniformis) and plume (Pterophorus spilodactylus) moths serve as effective biological controls while disturbed soils must be re-vegetated with ground covers to prevent horehound from re-establishing.

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