Anguish would most often be a mood. Tone is the way the words are written, so the writer might be anguished, but usually not.
mood sad tone depressing
stupid happy sad
The setting of the story does this.
Suspenseful is a tone
Tone is the kind of language used to set the mood.
the tone is the mood that the auther creats
not in the mood
what can be inferred about the mood, tone, and point of view of the author.
Mood
the tone of gifted hands was calm
what is the mood and tone of the poem silver
The mood is to live out loud.