No-one - he died a natural death.
In fact his name tells you that. A Confessor is a christian saint who died a natural death as distinct from say Edward the Martyr who died for his faith.
Edward V reigned April to June 1483 aged 12, unlawfully killed
The play is about Richard III, man who had been made guardian for a very young king, Edward V, who was 12. He is believed to have killed Edward, but certainly Edward disappeared and Richard took control of the kingdom. He did not last long, and was killed two years later at the Battle of Bosworth.
edward killed 234 including children !
Edward V. Whiton died in 1859.
Edward V. Whiton was born in 1805.
Edward V. Babcock died in 1948.
Edward V. Babcock was born in 1864.
Edward V. Curry died in 1982.
Edward V. Curry was born in 1909.
Edward V of England was born in Westminster, England.
Edward V. Hartford was born on 1870-##-05.
Edward V. Ramage died in 1981-12.