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.mingxinwrite It is known that the pRb pathway cell-cycle inhibitor p16(INK4A) plays a significant role in cutaneous melanoma and that alteration of p16(INK4A), which resides within the 9p21-22 locus that also contains p15(INK4B) and p14(ARF), may occur in up to one third of uveal melanomas. The absence of TGFbeta responsiveness noted in cultured uveal melanoma cells also suggests that the TGFbeta pathway plays a role in the formation of this tumor. Therefore, mutational screening was performed in several key genes in tumor-suppressor pathways that are known to be altered in some uveal melanomas.Using denaturing high-performance liquid chromatography (DHPLC) analysis and DNA sequencing, a series of 67 uveal melanomas were screened for inactivating mutations in the TGFbeta pathway members Smad4 and TGFbeta receptor type 2 (TGFbetaR2), the downstream cell-cycle inhibitor p15(INK4B), and the cell-cycle inhibitors p14(ARF) and p16(INK4A). p16(INK4A) was also investigated for promoter hypermethylation. Mutational analysis was also performed on the Wnt pathway gene beta-cate

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Is the subject line and topic the same things on an essay?

No, the subject line and topic are not the same in an essay. The subject line, which is commonly used in emails, is a brief description of the email's content. The topic of an essay is the main idea or subject that the essay will discuss in depth.


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What is a hook in writing a persuasive essay?

It is the beginning sentence that will naturally bring readers to your paper; it has to be something that will catch the person's eye and will help them decide that reading your essay is a good choice.


How do you use a hook for a differences essay?

To write a hook for a differences essay, you can start by using a powerful quote, posing a thought-provoking question related to the topic, or sharing an interesting fact or statistic. The hook should captivate the reader's attention and introduce the main theme of the essay, which is exploring and analyzing differences.


What are types of hooks used in persuasive essay's?

Some types of hooks used in persuasive essays include rhetorical questions, statistics or facts, anecdotes or personal stories, and powerful quotes or statements. These hooks are designed to grab the reader's attention and make them interested in reading more of the essay.

Related Questions

What pronoun is in the word essay?

The word essay is a noun. The pronoun used to represent essay is it. Note: the letters in 'essay' do not spell any pronoun.


What alternative word can be used instead of "we" in an essay?

An alternative word that can be used instead of "we" in an essay is "one" or "individuals."


Postage stamp prototype?

The normal name used is an 'essay.' Once it has been approved, there will be a plate created. That will be used to create 'proofs,' which are often used to create 'color trials.'


Is an analysis essay an essay used in psychoanalysis?

No, it's an essay that analyzes how the parts of something work together to create a whole.


What are the four types of essay types and what are they used for?

Expository essay explains a issue, theme or idea. Persuasive essay is presenting an opinion and trying to persuade other's to the same point of view. Analytical essay is used to analyze, examine, and interpret. Argumentative essay is used to prove a opinion, theory or hypothesis about an issue is correct.


How do you recycle household products What type of essay would be used for this topic?

Expository essay


What font does Sponge Bob use for his essay?

The font used in SpongeBob's essay is Comic Sans.


What should be used to replace "we" in an essay to enhance clarity and formality?

In an essay, the pronoun "one" can be used to replace "we" in order to improve clarity and formality.


What words are prohibited from being used in an essay?

Profanity, hate speech, discriminatory language, and offensive terms are prohibited from being used in an essay.


What type of essay informs or explains?

An expository essay is used to explain or inform. An argumentative essay attempts to persuade the reader to agree with the author.


What word can be used to replace you in an essay?

One


What are persuasive essays about?

A persuasive essay is an essay used to convince a reader about a particular idea, usually one that writer believe in, which is the main purpose of a persuasive essay.