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Look after the details, whether monetary or otherwise, and the larger issues will also be taken care of.

I.e., make sure you brush your teeth after breakfast every day (little thing) and your teeth (big thing) will be fine.

The term comes from British Coins which are denominated in pennies and pounds (= 100 pennies). The expression could be expressed in American terms as "If you're careful about pennies, you'll end up with a lot of dollars", but of course the meaning is much broader as noted.

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13y ago

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