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The initiation of hemostatic response refers to the body's immediate reaction to vascular injury, aiming to prevent blood loss. This process begins with vascular constriction and the exposure of collagen and tissue factors, which activate platelets. Platelets adhere to the injury site, becoming activated and releasing substances that recruit additional platelets, forming a temporary plug. This initial response is crucial for stabilizing the injury and setting the stage for subsequent hemostatic processes, such as coagulation.

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