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The stability of a conformation is primarily influenced by steric interactions, torsional strain, and electrostatic interactions. Steric hindrance occurs when bulky groups are positioned too close to each other, leading to increased energy and decreased stability. Torsional strain arises from eclipsing interactions between atoms or groups during rotation around bonds, while electrostatic interactions can either stabilize or destabilize a conformation based on the distribution of charge. Overall, a more stable conformation minimizes these unfavorable interactions.

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2mo ago

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