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Two prominent groups that fought against Prohibition were the Anheuser-Busch brewery and various women's organizations, notably the Women's Organization for National Prohibition Reform (WONPR). Anheuser-Busch and other breweries opposed Prohibition as it threatened their businesses and livelihoods. Meanwhile, women's groups argued that Prohibition had led to increased crime and corruption, and they sought to highlight the negative impacts of the law on society. Together, these groups played significant roles in advocating for the repeal of Prohibition.

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