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According to Drug War Facts, the answer is 0.

An exhaustive search of the literature finds no credible reports of deaths induced by marijuana. The US Drug Abuse Warning Network (DAWN) records instances of drug mentions in medical examiners' reports, and though marijuana is mentioned, it is usually in combination with alcohol or other drugs. Marijuana alone has not been shown to cause an overdose death.

In addition:

The primary active ingredient in marijuana is tetrahydrocannibinol or THC. However, this is somewhat misleading, in that the effects one experiences when sampling marijuana are derrived from a rainbow of canniboid halluncinogens and intoxicants, all related to but not exactly the same as THC. As plants tend to formulate compounds in wildly varying amounts, one cannot know how much THC or other active ingredients -- if any -- will be delivered from one plant, one leaf, etc.

Turning towards studies that used pure THC or Drabinol -- synthetic THC (which appears to be different enough to be pharmacologically out of parallel with naturally occurring THC), we find that the usual recreational dosage is roughly 10-15mg/kg for a normal human and as much as 75mg per dose for oncology patients. We also find that the LD50 (Lethal Dose 50%) of THC is 1,270mg/kg for male rats. Doing the arithmetic for humans, we find that it takes about 300gm of pure THC to acheive lethality in 50% of the test cases, which amounts to roughly 30,000 marijuana cigarettes (assuming 10mg per cigarette).

Under the circumstances, we can honestly say that THC and marijuana in general is not directly very toxic to humans at all, and it's no surprise that there are no recorded, substatiated fatalities resulting from marijuana/THC overdose.

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10y ago

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