Interstate 10 and 45
You could use Interstate 10.
Interstate 10 through Houston, Texas, United States
Interstate Highway 10.
Take I-10 WEST to San Antonio.
I have traveld I 10 from Jacksonville thru New Orleans with no problems.AnswerThe last I traveled it from Houston to Lake Charles, yes it was definitly open. This was last month. I-10 is always open .. more or less. There is always construction somewhere. You can check online to see if there are closures in the states through which you will be traveling;http://www.highwayconditions.com/united_states.htmYes, it is always open
Phoenix to Houston via I-10 East is 1,177 mi – about 16 hours 23 mins per Google Maps.
It is on Interstate 45.
To leave San Antonio for Houston, take Interstate 10 (I-10) East. You can start by getting on I-10 from various points in San Antonio, depending on your location. The drive will take you through cities like Seguin and Columbus before reaching Houston. Make sure to follow signs for I-10 East to stay on the correct route.
Interstate Highway 45, or old Highway 75.
Interstate 57.
Houston, Texas has 'The Loop' (Interstate 610).