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When you use antibiotics that are effective above minimal inhibition concentration (MIC), you shouldnt let the concentration in serum go under this value. When the concentration is higher, bacterias are dying. When the concentration gets below MIC, you "give a rest" to the bacterias and they can reproduce. Kind of logically, those who are going to reproduce survived the first ATB doses, so they have some advantage in their genom and this advantage is going to propagate to the next generations. This repeats as long as the bacteria become completely resistent to a certain ATB.

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