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Methotrexate
Methotrexate is a chemotherapy and immunosuppressant. It is commonly used to treat autoimmune diseases, such as rheumatoid arthritis and psoriasis. It is also used in the treatment of several types of cancer, such as leukemia or breast cancer. It can have serious side effects, and the use should be closely monitored by a doctor.
187 Questions
What do you do if you have taken nurofen when you are on methotrexate?
Nurofen is the Australian name for Ibuprofen and the the following is what is sited about interactions between the drugs you mentioned.
MONITOR CLOSELY: Coadministration with nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the plasma concentrations and toxicities of methotrexate. The proposed mechanism is NSAID inhibition of the renal elimination of methotrexate and its metabolite, 7-hydroxymethotrexate, although data from pharmacokinetic studies are inconsistent and conflicting. Displacement of methotrexate binding to serum albumin by certain NSAIDs may also play a secondary role. Unexpectedly severe and sometimes fatal bone marrow suppression, aplastic anemia, gastrointestinal toxicity, and nephrotoxicity have been reported during concomitant administration of methotrexate with NSAIDs. The risk is greatest in patients receiving high dosages of methotrexate and those with renal impairment. In clinical studies, methotrexate at dosages of 7.5 to 15 mg/week has been used without apparent problems in patients with rheumatoid arthritiswho also received constant dosage regimens of NSAIDs. However, there have been occasional reports of stomatitis, pneumonitis, bone marrow toxicity, and fatality in patients receiving low-dose weekly methotrexate with daily NSAIDs.
MANAGEMENT: NSAIDs should generally not be administered prior to or concomitantly with high dosages of methotrexate, such as those used to treat osteosarcoma. Caution should be exercised when NSAIDs are administered concomitantly with lower dosages of methotrexate. Close monitoring for signs and symptoms of bone marrow suppression, nephrotoxicity, and hepatotoxicity is recommended during treatment. Patients should be advised to contact their physician if they develop stomatitis, nausea, vomiting, diarrhea, rash, anorexia, jaundice, dark urine, dry cough, shortness of breath, and/or signs and symptoms of myelosuppression such as pallor, dizziness, fatigue, lethargy, fainting, easy bruising or bleeding, fever, chills, sore throat, body aches, and other influenza-like symptoms. Patients should also be counseled to avoid any other over-the-counter NSAID products.
The Technician, when accidentally having skin contact with a cytotoxic drug, should wash hands thoroughly with soap and water immediately and seek medical attention.
Can methotrexate cause diarreha?
Methotrexate may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
dizziness
drowsiness
headache
swollen, tender gums
decreased appetite
reddened eyes
hair loss
Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:
blurred vision or sudden loss of vision
seizures
confusion
weakness or difficulty moving one or both sides of the body
loss of consciousness
Methotrexate may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
I did not see any Side Effect of diarrhea.
This is a serious drug, any questions you may have, contact your doctor.
Methortexate is not safe with pregnancy, and can potentially cause a miscarriage. If you plan on getting pregnant, you need to have a conversation with your doctor.
Like anything else in like, it depends. What's the dose taken? How strong was person's immune system before taking mtx?
I have been on mtx for 6 months now including flu season and I didn't catch it or anything else, but I have always been healthy that way and cannot remember the last time I had the flu.
Is it safe to take Ambien CR and Methotrexate?
There are no known interactions between Ambien CR and methotrexate. It is advisable to make sure your doctor has a full list of all the medications you are on, even if they were given to you by other doctors.
Methotrexate how many does for rheumatoid arthritis?
Methotrexate is a dangerous drug and needs to be given under the supervision of a trained professional The dose varies depending on the patient. regular blood tests need to be taken to test for toxicity and other problems. ie This stuff can kill you if it is not administered properly.
What will methotrexate do to you if you have been wrongly diagnosed?
If you are taking it methotrexate for rheumatoid arthritis, you are doing it to reduce the destructive effects that your own immune system is having on cartilage in your joints and other connective tissue. Methotrexate need to be taken along with folic acid as it takes folic acid out of the system. People that use methotrexate need to be checked regularly with blood test to see if there is any toxin build up in the kidneys. However if you have been incorrectly diagnosed it hardly matters as the side effects ( and there are heaps of them) would be the same either way.
Is methotrexate a form of morning after pill?
No. It is a drug which prevents cells dividing and is usually used for cancer, psoriasis and rheumatoid arthritis. It's only use around fertile women who may be pregnant is to induce miscarriage in cases of ectopic pregnancy. If taken during a possibly normal pregnancy it can cause severe birth defects.
Can you take levitra with methotrexate?
There does not appear to be any interactions between these two drugs, but a physician or pharmacist should be consulted anyway for the most recent drug information.
Very occasionally the fertilised ovum starts dividing rapidly and instead of forming a placenta and baby it forms a hydatidiform mole. Many women miscarry this completely, but some go into the second trimester still carrying and have to have the tissue removed. See the accompanying link as to why it is extremely important that you have all the follow up tests.
What should I take in place of methotrexate?
If you're looking for alternatives to methotrexate, it's essential to consult your healthcare provider for personalized advice, as alternatives can vary based on the condition being treated. Common alternatives for conditions like rheumatoid arthritis include biologics (e.g., adalimumab, etanercept) or other disease-modifying antirheumatic drugs (DMARDs) like sulfasalazine or leflunomide. Your doctor can help determine the most appropriate option based on your specific medical history and needs.
What are the benefits of taking naproxen with methotrexate?
Taking naproxen with methotrexate can provide pain relief and reduce inflammation for conditions like rheumatoid arthritis, where methotrexate is used as a disease-modifying antirheumatic drug. Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), can help manage symptoms such as pain and swelling, improving the patient's overall comfort and quality of life. However, it's essential to monitor for potential interactions and side effects, as both medications can affect kidney function. Always consult a healthcare provider before combining these treatments.
How does methotrexate affect leukocyte?
Methotrexate affects leukocytes by inhibiting their proliferation and function through the inhibition of dihydrofolate reductase, which is crucial for DNA synthesis and cell division. This leads to a reduction in the production of white blood cells, particularly lymphocytes, thereby suppressing the immune response. As a result, methotrexate is often used in the treatment of autoimmune diseases and certain cancers to control hyperactive immune activity or tumor growth. However, this immunosuppressive effect can increase the risk of infections.
Can you take methotrexate and topiramate?
There has been some speculation that grapefruit can have an effect on methotrexate levels in your body, but there is not any real evidence that it is true. There is not enough of a concern to list it in the medication precautions.
Can you take boswellia while taking methotrexate?
Boswellia is an herbal supplement that may have anti-inflammatory properties, but its interactions with methotrexate are not well-studied. While some individuals may use boswellia alongside methotrexate without issues, it's crucial to consult with a healthcare provider before combining them. This ensures that any potential interactions or side effects are properly managed. Always prioritize professional guidance when considering supplements with prescription medications.
Can you mix NyQuil and methotrexate?
Though it's hard to say, depending on which NyQuil you would use, as each NyQuil has different drugs and a combination of them in it (NyQuil Cough, NyQuil Cold & Flue, etc.), it doesn't seem like there would be an interaction between the two.
