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Prions

A prion is an infectious agent consisting of a protein that is mis-folded. It can cause several central nervous system diseases. Included are Creutzfeldt-Jakob Disease, Fatal Familial Insomnia and Kuru in humans plus Scrapie in sheep.

134 Questions

Are prions worse than viruses because prions are virtually unstoppable?

All prion diseases are inevitably fatal; there are no known cures. You can inactivate them, not kill them. They are technically not alive. Think of them more like a substance, a protein to be exact.

Can a person who ate prion infected food using hands cross-contaminate other things if he touches them after touching food infected with prions if they attached to its hands?

Yes a person who ate prion infected food using hands can cross-contaminate other things if he touches the food infected with prions with his hands.

Do class b sterilizer kill prions?

Prions are only destroyed by:

• incineration

• autoclaving in 1N NaOH

What systems do prions affect?

Prions primarily affect the nervous system by causing misfolding of proteins, leading to neurodegenerative diseases like Creutzfeldt-Jakob disease and mad cow disease. However, recent research shows that prions can also affect other cells and tissues in the body, impacting the immune system and possibly playing a role in conditions like Alzheimer's disease and Parkinson's disease.

What organic molecule is a prion?

A prion is a misfolded form of a protein molecule, specifically the prion protein (PrP). It can induce other normally folded PrP proteins to adopt the misfolded conformation, leading to the spread of prion diseases.

Are prions just viruses that lack a capsid?

A prion is a small infectious particle that contains a protein. These contain no DNA or RNA. These cause Creutzfeldt-Jakob disease, Scrapie in sheep and Kuru. These are deadly and progressive nerve wasting diseases.

Are mutated prions shaped like a rod?

Mutated prions have an altered conformation of their normal prion protein shape, leading to misfolding. In the misfolded state, prions form aggregates and can have various shapes, depending on the specific mutation. While some may resemble rod-like structures, prions can also form sheets, fibrils, and other irregular shapes.

How things like a virus prion and viroid can reproduce but are not considered to be alive?

The virus, prion and viroid don't meet the definition of alive which is:

  • Movement: All living things move in some way.
  • Respiration: Respiration is a chemical reaction that happens within cells to release energy from food.
  • Sensitivity: The ability to detect changes in the environment.
  • Growth: All living things grow.
  • Reproduction: The ability to reproduce and pass genetic information onto their offspring.
  • Excretion: Getting rid of waste.
  • Nutrition: The intake and use of nutrients.

All living things do all of these things. Viruses make use of living cells.