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It is possible that the earliest recorded opinion of tobacco, especially the smoking of, as harmful to health would be the Counterblast to Tobacco written in 1604 by James I of England. In this, at the time anonymous, pamphlet he says that smoking is "hurtful to the health of the whole body" and affects the "inward parts of men [by] fouling and infecting them with an unctuous and oily kind of soot as hath been found in some great tobacco-takers that after their death were opened." He also notes that it is "a custom loathsome to the eye, hateful to the nose, harmful to the brain, dangerous to the lungs."

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