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The three major waterways of the Northwest Territory—the Ohio River, the Mississippi River, and the Great Lakes—were crucial for transportation and trade, facilitating the movement of goods and people. They enabled agricultural expansion by providing access to markets, encouraging settlement and economic growth in the region. Additionally, these waterways served as natural boundaries and influenced territorial disputes, shaping the political landscape. Overall, they played a significant role in the social and economic development of the Northwest Territory.

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