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The chief commercial city of the Tigris and Euphrates River system was Babylon. Located in ancient Mesopotamia, Babylon became a significant center for trade, culture, and politics, especially during the reign of King Nebuchadnezzar II. Its strategic location along the rivers facilitated commerce and enabled it to flourish as a hub of civilization. Babylon is also well-known for its impressive architecture and contributions to law, such as the Code of Hammurabi.

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