Alligator has nine letters, but the word only has four vowels.
Queue
Rake perhaps?
Deceive
Headache starts and ends with the letters he. Another word is heartache.
Ambulance starts with a and ends in e. It's a noun with 5 consonants, 4 vowels.
Dominique
"TOURIST"
Lighthearted is a 12 letter word. Lithographed is another 12 letter word that starts with L and ends with D.
angina aurora another one......amoeba
asthma
gypsy pygmy
queue