Main Drugs/Classes are: Cisplatin Loop Diuretics Aminoglycosides Vancomycin Edit: <<While I'm sure many things cause otoxicity and nephrotoxicity; the major example that springs to mind is aminoglycocides (gentomicin/streptomicin)>>
I'm pretty sure Gentamycin is the only one that does both... You might want to do some research of your own starting with that and see what others you can find.
Aminoglycosides can potentially damage the kidneys and the inner ear, leading to nephrotoxicity (kidney damage) and ototoxicity (hearing loss or balance problems). Close monitoring of kidney function and hearing is important when using these antibiotics.
Some of the most toxic antimicrobial agents to humans include aminoglycosides, such as gentamicin, which can cause nephrotoxicity and ototoxicity. Chloramphenicol is another agent known for its potential to cause aplastic anemia and bone marrow suppression. Additionally, polymyxins, like polymyxin B and colistin, can lead to significant nephrotoxicity and neurotoxicity. Careful monitoring and dosage adjustments are essential to mitigate these risks when using these agents.
Many drugs can cause ototoxicity. Antibiotics: amikacin (Amikin), streptomycin, neomycin, gentamicin (Garamycin).
When kidney function is impaired, gentamicin, an aminoglycoside antibiotic, can accumulate in the body, leading to an increased risk of toxicity. This can cause nephrotoxicity, which may further worsen kidney function, and ototoxicity, affecting hearing and balance. Therefore, careful monitoring of kidney function and dosage adjustments are crucial when administering gentamicin to patients with impaired renal function.
Ototoxicity often goes undiagnosed. This occurs when the hearing loss is slight, or when it is restricted to the higher frequencies. Patients may notice a change in their hearing, but it may not be significant enough to report.
There are no current treatments to reverse the effects of ototoxicity. People who suffer permanent hearing loss may elect to use hearing aids, or, when appropriate, receive a cochlear implant. For those who have balance problems.
The prognosis depends on the drugs that caused the ototoxicity, and their dose. The aminoglycoside antibiotics, gentamicin, kanamycin, netilmycin and tobramycin all cause hearing loss to varying degrees. These drugs may be used.
Nephrotoxicity
Since most ototoxicity occurs when the harmful drugs are used in high doses, careful dose calculations are the best method of prevention. Sometimes it is possible to replace the ototoxic drugs with drugs that have less severe adverse effects.
Yes, regular use of ibuprofen can potentially cause ototoxicity, which is damage to the ear and hearing. It is important to consult with a healthcare professional before using ibuprofen regularly to understand the potential risks and benefits.