The word "spout" fits your criteria, with the second letter being 'p' and the fourth letter being 'u'. If you have specific contexts or additional criteria in mind, feel free to share!
guppy, puppy, bumpy, jumpy
Delphi
open
The second letter is P. It comes right after the i, and before the a.
limp
pancakes pancetta
appeal
apiece
spruce, opaque
P is for phony.
Phthisic is pronounced tiz-ik so the ph and the second h are silent.
Operas,opener,or sparse