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Yes, colonists from North Carolina had varied relationships with Native American tribes, including both cooperation and conflict. Initially, some settlers engaged in trade and formed alliances with tribes such as the Tuscarora and the Catawba, often relying on their knowledge of the land. However, as colonization expanded, tensions grew, leading to violent confrontations like the Tuscarora War in the early 18th century. Overall, the interactions were complex and evolved over time, shaped by the colonists' expansionist goals and the native populations' responses.

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