I - 95 does not go to Columbus, OH. You will have to take another route.
About 670 miles.
425 miles
The city that is halfway between Columbus, OH, and Fort Lauderdale, FL, is Mooresville, NC. When traveling such a long distance, stopping overnight at the halfway point is a good idea.
about a day and 3 hours in car
Anywhere from two days to two weeks.
6 hours 20 mins driving..... 379 miles
The shortest driving time is 10 hours and 43 minutes.
Greenville, OH
Why don't you just mapquest It
If you take I-95 there are no tolls in NC or Virginia. As of a couple years ago, there were none in SC either.
A typical flight between Cincinnati, OH and Greenville, SC would have a flying time of about 38 minutes.
The driving distance between Columbus, OH and Charlotte, NC is approximately 425 miles. The driving time would be approximately 7 hours if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work, border crossings and rush hour traffic in urban areas.)