161 miles by road.
See the link below.
leeds is in wales
Road miles between London UK to he city of Holyhead Wales UK
Holyhead is in the northwest corner of Wales. See the map at the link below.
Wales is a big place ! Salisbury to Cardiff for example is just over 94 miles - whereas Salisbury to Holyhead is 292 miles.
The distance between Manchester, England and Holyhead, Wales is about 120 road miles or 193 km.
Actual distance will depend on which road you choose to use, but using the line measure tool on Google Earth, Holyhead is about 218 miles (351 kilometers) northwest of Heathrow Airport.
If you meant Holyhead in Wales - it's a journey of roughly 256 miles, and would take about 4.5 hours by road.
160 miles taking this route:Take A55, from Holyhead, to M56 MANCHESTER. Follow signs.Take M56 across to M6(N) to LEEDS and MANCHESTER (N) (via M62) at J9.Take M6 to M62 to LEEDS and MANCHESTER (N) at J21A.Take M62 across to LEEDS, via M60 RING ROAD (N) around Manchester.
Euston
Holyhead, Isle Of Anglesey to Gosport, Hampshire = 331.1 miles.
It is about 291 miles by car from Holyhead, Isle of Anglesey, UK to Birgham, Scottish Borders, UK.
About 85 miles.