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It's 260 highway miles between the two cities. Driving at 60 mph, it takes 4 hours and 20 minutes; at 70 mph, it takes 3 hours and 45 minutes. Flying, it takes one hour and 50 minutes (not counting the time spent going through security, waiting on the flight, boarding, etc.) Amtrak doesn't run directly between St Louis and Louisville.

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16y ago

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