The driving distance between Louisville, KY and Knoxville, TN is approximately 245 miles. The driving time would be approximately 4 hours if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work and rush hour traffic in urban areas.)
Louisville is around mile 601 of the river. Cincinnati is at roughly mile 471 making it 130 miles. You can stretch it a mile or two either way at either end.
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louisville and Cincinnati louisville and Cincinnati
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Mapquest it.
Both Louisville and Cincinnati are in the Eastern Time Zone.
It is 2567.42 miles according to MapQuest.
Distance from Louisville to Cincinnati is 96 miles or 83 nautical miles. Source: Time and Date.com
It is 106.67 miles according to MapQuest.
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The Keg of Nails.