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Estimates suggest that opium addiction led to millions of deaths in China during the 19th and early 20th centuries. The Opium Wars and the subsequent social and health crises caused by widespread opium use contributed to significant mortality rates, but precise figures are difficult to determine. Some historians estimate that millions may have died directly or indirectly from opium-related causes, including health deterioration and social disruption. The impact of opium addiction on Chinese society was profound and long-lasting.

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