No
The constellations near the plane of the ecliptic (the zodiacal constellations) are only visible at certain times of the year. The constellations towards the poles (N and S) are visible at all times of the year from their respective hemispheres. In the South, the Southern Cross would be one example and in the North the Great Bear (or plough) would be another.
Their primary navigation aid would have been the North Star. As accurate time pieces had not yet been created, they had no way of determining their longitude and the stars did little to assist them.
Based on the other constellations I would say no.
Sahara
Mediterranean Sea
Mediterranean Sea
The Southern Cross is not an actual object. The constellations are ways of grouping stars in ways that make sense to earth observers. The stars of this constellation may or may not be in reasonable proximity to one another, but in any event, you would have to consider the distances of each individual star. See link for more. Three of the four stars in the Southern Cross are at approximately the same distance. They are the two brightest ones and the faintest one, which are between 600 and 680 light years away. The other one is at about one fifth the distance, 135 light years.
To find circumpolar constellations, look towards the north if you are in the Northern Hemisphere or towards the south if you are in the Southern Hemisphere. Circumpolar constellations are visible all year round and appear to "circle" around the celestial poles without setting below the horizon.
The Australian flag or the ski.
While the Egyptians used many of the same constellations as markers, they used them for determining direction and the time of year, e.g. when the Nile would flood.
you would sell more goods in LOWER (meaning Northern because that's the lower part of the river) Egypt, because that's where the Nile Delta is located, which is a major trade corridor. From the Nile Delta, ships can go by water to the Mediterranean, which can help the merchants get to Southern Europe and the Middle East. The Nile Delta is also close to Egypt's Capital and most populated city, Cairo, which is in the NORTHERN part of the country. Merchants could sell in Cairo, because of all the people there. The Sahara Desert is located in Southern Egypt. Because of this, SOUTHERN Egypt has the lowest population density of the whole nation. The only people that are there are nomadic herders, and merchants who travel by camel. So to answer this question, if you were a merchant in Egypt, you would sell more goods in NORTHERN (or lower) Egypt than in Southern Egypt. North is above, and Southern is below. Look it up
If constellations disappeared, stargazing and navigation by the stars would be more challenging. However, the celestial objects themselves would still exist. Constellations are simply patterns that we've formed by connecting stars in the sky, so their disappearance would not affect the stars themselves.