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Yes, Ohio is East of the Mississippi River. To clarify this, look at a map of the United States of America, preferably today and look towards the Eastern side of the map, and you'll notice that the Mississsippi River runs from Louisiana, all the way up to the Central-Eastern border of Minnesota. Additionally, three states are east of the Missisippi River in the Midwestern US: Missouri, Illinois & Indiana ---- Indiana is West of Ohio, Canada is North of Ohio, West Virginia, is Southeast of Ohio, Pennslyvania borders Ohio towards the East, and finally, Northeastern & Extreme Northeastern Kentucky borders the Southern border of the US State of Ohio, or just "Ohio."

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