The key Confederate port city captured in April 1862 was New Orleans, Louisiana. The Union Navy, led by Admiral David Farragut, successfully took control of the city on April 25, 1862, effectively blocking a vital supply route for the Confederacy. This capture was significant as it diminished Confederate access to the Mississippi River and was a major blow to their war efforts.
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Admiral Farragut
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The first Confederate city captured by the Union Army was New Orleans in 1862. New Orleans was the largest port city in the Confederacy. By the end of the war, the Union had also captured Mobile, Savannah, Charleston, and Wilmington in order to deprive the Confederacy of supplies.
The last port city captured by the Union during the American Civil War was Wilmington, North Carolina. The Union forces took control of Wilmington on February 22, 1865, following a series of military engagements. This capture was significant as Wilmington had been a crucial supply port for the Confederacy. The fall of Wilmington further restricted Confederate access to resources and contributed to the eventual defeat of the Confederacy.
Originally I asked what was the first large Confederate city to fall in the US Civil War, however, this question may suffice. In terms of a major city, it would be the port city of New Orleans. This was important as it layat the mouth of the Mississippi River. Union Admiral Farragut was in charge of the victorius battle.
The city captured by a Union fleet that cut off the Confederacy from receiving supplies was New Orleans. This significant event occurred in April 1862, when Union forces took control of the city, which was a vital port for Confederate trade and supply routes. The capture of New Orleans significantly weakened the Confederacy's ability to sustain its war efforts.
The last Confederate port to hold out against the Union was Wilmington, North Carolina. It remained under Confederate control until January 15, 1865, when Union forces captured Fort Fisher, which guarded the port. This loss significantly impacted the Confederacy's supply lines and marked a turning point in the Civil War. Wilmington's fall effectively closed the last major open port for the Confederacy.
Charleston, SC New Orleans, LA Galveston, TX (for awhile)
Port royal was captured several times, but was definitively captured in October 1710.
In 1864, Admiral David Farragut captured the southern port of Mobile, Alabama. This significant victory for the Union occurred during the Battle of Mobile Bay, which was fought in August of that year. The capture of the port helped to further restrict Confederate supply routes and marked a key moment in the naval campaign of the Civil War.
At the same time in March of 1862, when Brigadier General Burnside was capturing New Bern and Roanoke Island, the Union Navy was also active. The Navy captured Elizabeth City, North Carolina and sank or burned four Confederate gunboats. It also captured one as well. The Navy then chased two more enemy gunboats and obstructed the waterway between Elizabeth City and the port of Norfolk.