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Jamestown faced several significant disadvantages, including harsh environmental conditions, such as swampy land and a lack of fresh water, which led to diseases like malaria. The colonists also struggled with inadequate supplies and food shortages, exacerbated by conflicts with Indigenous peoples and poor planning. Additionally, the initial governance and leadership issues created instability and hindered the colony's ability to thrive. These factors contributed to high mortality rates and significant challenges in establishing a sustainable settlement.

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