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  1. Take I-70 WEST to I-81 NORTH & SOUTH to HARRISBURG and ROANOKE at EXIT 26.
  2. Exit at EXIT 26A onto I-81 SOUTH to ROANOKE. Take I-81 SOUTH all the way down to I-40 WEST to KNOXVILLE at EXIT 1B in Tennessee. This is where I-81 ENDS.
  3. Take I-40 WEST to Oklahoma City. There are a few bypasses that you need to worry about. In Tennessee you are going to bypass Knoxville by taking I-640 WEST (EXIT 393 off I-40) and you are also going to bypass Nashville, Tennessee by taking I-440 WEST (EXIT 213A off I-40).
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